PUBLICATIONS
1. Damania, B. and J.C. Alwine. TAF-like function of SV40 large T antigen. Genes Dev.1996.11:1369-81.
2. Damania, B, Lieberman, P. and J.C. Alwine. Simian virus 40 large T antigen stabilizes the TATA-binding protein-TFIIA complex on the TATA element. Mol. Cell Biol., 1998. 18(7):3926-3935.
3. Damania, B., Mital, R. and J.C. Alwine. Simian virus 40 large T antigen interacts with human TFIIB-related factor and small nuclear RNA-activating protein complex for transcriptional activation of TATA-containing polymerase III promoters. Mol. Cell Biol., 1998. 18(3)1331-1338.
4. Damania, B, Li M, Choi JK, Alexander L, Jung JU, Desrosiers RC. Identification and characterization of the R1 oncogene and its protein product from the rhadinovirus of rhesus monkeys. J. Virol., 1999. Vol. 73(6), pp. 5123-5133.
5. Damania, B. Lee, H. and Jung, J.U. Primate herpesviral oncogenes. Mol. Cells 1999. 9 (4)20-24.
6. Damania, B., Choi, J.K. and Jung J.U. Signaling activities of gammaherpesvirus membrane proteins. J. Virol. 2000. 74 (4) 1593-1601.
7. Damania, B. DeMaria, M.., Jung, J.U. and R.C. Desrosiers Activation of lymphocyte signaling by the R1 protein of Rhesus rhadinovirus. J. Virol. 2000 74 (6).2721-2730.
8. Alexander, L., Denekamp, L., Auerbach, M., Knappe, A., Damania, B and R.C. Desrosiers The primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence similarities to Kaposi’s sarcoma-associated herpesvirus and rhesus rhadinovirus isolate 17577. J. Virol. 2000 74 (7).3388-98.
9. Lee, B.S., Damania, B, and J.U. Jung. The Kaposi's sarcoma-associated herpesvirus K1 and Rhesus Monkey Rhadinovirus R1 proteins. EBV Report. 1999. 6 (5)123-125.
10. Li, M., Damania, B. Alvarez, X., Ogryko, G., Ozato, K., and J.U. Jung. Inhibition of p300 histone acetyltransferase by viral interferon regulatory factor. 2000. Mol. Cell Biol. 20(21):8254-8263.
11. Damania, B and J.U. Jung. Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi’s sarcoma-associated herpesvirus and herpesvirus saimiri. 2001. Adv. Cancer Res. 80:p51.
12. Damania, B. and R.C. Desrosiers. Simian homologues of human herpesvirus 8. Philos Trans R Soc. Lond B. Biol. Sci. 2001. 356(1408):535-543.
13. Choi JK, Means R, Damania, B., and J.U. Jung. Molecular piracy of Kaposi’s sarcoma associated herpesvirus.2001. Cytokine and Growth Factor Rev. 12(2-3):245-257.
14. DeWire, S., McVoy,, M., and B. Damania. Kinetics of Expression of Rhesus Monkey Rhadinovirus (RRV) and the Identification and Characterization of a polycistronic transcript encoding the RRV Orf50/Rta, RRV R8 and R8.1 genes. 2002. J. Virol. 76(19): 9819-9831.
15. Bowser, B.S., DeWire, S. and B. Damania. Transcriptional Regulation of the KSHV K1 viral gene of Kaposi’s sarcoma-associated herpesvirus. 2002. J. Virol., 76 (24): 12574-12583.
16. DeWire, S.M., Money, E.S., Krall, S.P., and B. Damania. Rhesus Monkey Rhadinovirus (RRV): Construction of a RRV-GFP Recombinant Virus and the Development of Assays to Assess Viral Replication. 2003. Virology. 312 (1): 122-134.
17. Yu, X.K., O’Connor, C., Atanosov, I., Damania, B., Kedes, D., and Z.H. Zhou. Three-Dimensional Structures of the A, B, and C Capsids of Rhesus Monkey Rhadinovirus: Insights into Gammaherpesvirus, Capsid Assembly, Maturation and DNA Packing. 2003. J. Virol. 77: 13182-13193.
18. O’Connor, C., Damania, B. and Kedes, D.H. De Novo Infection with Rhesus Monkey Rhadinovirus Leads to the Accumulation of Multiple Intranuclear Capsid Species during Lytic Replication but Favors the Release of Genome-Containing Virions. J. Virol. 2003. 77: 13439-13447.
19. Tomlinson, C.C., and B. Damania. The K1 Protein of Kaposi’s Sarcoma-Associated Herpesvirus Activates the Akt Signaling Pathway. J. Virol. 2004. 78 (4): 1918-27.
20. Damania B., J. H. Jeong, B. S. Bowser, S. M. DeWire and D. P. Dittmer. “A Functional Comparison of Rta Transactivator Proteins of Gamma-2 Herpesviruses.” J.Virol. 2004. 78. p.5491-5499
21. Wang, L., Wakisaka N., Tomlinson, C., DeWire S., Krall, S., Pagano, J. and B. Damania. “The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV8) K1 Protein Induces Expression of Angiogenic and Invasion Factors.” Cancer Research. 2004. 64. pp.2774-2781
22. Damania, B. Modulation of cell signaling pathways by Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV-8). Cell Biochemistry & Biophysics, 2004. 40(3):305-22.
23. Damania, B. Oncogenic Gammaherpesviruses: Comparison of Viral Proteins involved in Tumorigenesis. Nature Reviews Microbiology, 2004. Vol. 2. pp.656-668.
24. Pagano, J.S. Blaser, M. Buendia, M.A., Damania, B., Khalili, K. Raab-Traub, N., Roizman, B. Validation Of A Causal Relationship: Criteria To Establish Etiology. Seminars in Cancer Biology. 2004. Semin Cancer Biol. 14(6):453-71.
25. Payton, M, d’Offay, J.M., Prado, M.E., Black, D.H., Damania, B., White, G.L., R. Eberle. Comparative Transmission of Multiple Herpesviruses in a Baboon Breeding Colony. Comp Med. 2004 54(6):695-704.
26. DeWire, S. and B. Damania. “The latency-associated nuclear protein of rhesus monkey rhadinovirus (RRV).” J. Virol. 2005;79 3127-3138.
27. Dittmer, D.P., Gonzalez C.M., Vahrson, W., DeWire, S.M., and B. Damania. “Whole-Genome Transcription Profiling of Rhesus Monkey Rhadinovirus.” J Virol. 2005; 79(13):8637-50.
28. Cai, W., Lu, S., Zhang, Z., Gonzalez, C. Damania, B., and B. Cullen. “Kaposi’s sarcoma associated herpesvirus expresses an array of novel viral microRNAs in latently infected cells. 2005. Proc. Natl. Acad. Sci. 102; 15. 5570-5575
29. Wong, EL and B. Damania. Linking KSHV to Human Cancer. Curr Oncol Rep. 2005 7(5):349-56.
30. Hong, G., Kumar, P., Wang, L., Damania, B., Gulley, M.L., Delecluse H-J., Polverini, P., and S. Kenney. Epstein-Barr Virus Lytic Infection is Required for Efficient Production of the Angiogenesis Factor VEGF in Lymphoblastoid Cell Lines. 2005. J Virol. 2005. 79(22):13984-92.
31. Wong, E.L. and B. Damania. Transcriptional regulation of the KSHV K15 promoter. 2006. J. Virology 80(3):1385-92.
32. Bilelo, J.P., Morgan, J.S., Damania, B., Lang, S.M., and R.C. Desrosiers. A Genetic System for Rhesus Monkey Rhadinovirus: Use of Recombinant Virus to Quantitate Antibody-Mediated Neutralization. 2006. J. Virology. 80(3):1549-62.
33. Gonzalez, CM, Wong, EL., Bowser, BS, Hong,G., Kenney SC and B. Damania. Identification and Characterization of the KSHV Orf49 protein. 2006. J Virol. 80(6):3062-70.
34. Wang, L., Dittmer, D. P., Tomlinson, C.C., Fakhari, F.D. and B. Damania. “Immortalization of primary endothelial cells by the K1 protein of Kaposi’s sarcoma-associated herpesvirus (KSHV). 2006. Cancer Res. 66(7):3658-66.
35. Bowser, B.S., Song, M.J., Sun, R., Morris, S. and B. Damania. “Identification of Multiple Rta Responsive Elements in the KSHV K1 promoter.” 2006. Virology. 348(2):309-27.
36. Hoon-Sin,S., Roy,D., Wang,L., Staudt M.R., Fakhari,FD., Patel,DD. Koon,H., Damania, B. and DP Dittmer. Rapamycin is efficacious against primary effusion lymphoma. Blood. 2007 Mar 1;109(5):2165-73
37. Damania, B. DNA tumor viruses and human cancer. Trends Microbiol. 2007. 15(1):38-44.
38. Mark, L., Spiller, BO., Okroj, M., Chanas, S., Aiken, J., Wong SW, Damania, B., Blom, AM and DJ Blackbourn. Molecular characterisation of the Rhesus Rhadinovirus (RRV) ORF4 gene and the RRV complement control protein (RCP) it encodes. 2007. J. Virology. 81(8):4166-76.
39. Nun, T., Kroll D.,Oberlies,N.,Wang, L., Dittmer, DP., and B. Damania. Development of a Novel, High Throughput Assay to Screen Anti-Viral Drugs against Kaposi’s Sarcoma-Associated Herpesvirus. 2007. Molecular Cancer Therapeutics. 6(8):2360-70.
• This article was highlighted in Cell-Based Assay News. Sep 7, 2007.
40. Dittmer, D and B. Damania. KSHV-Associated Diseases in the AIDS Patient. Cancer Treat Res. 2007;133:129-39.
41. West, J and B. Damania. Upregulation of the TLR3 pathway by KSHV. 2008. Journal of Virology. 82(11):5440-9.
42. Tomlinson, CC and B. Damania. A critical role for endocytosis in KSHV K1 signaling. 2008. Journal of Virology. 82(13):6514-23.
43. Wang, L. and B. Damania. KSHV confers a survival advantage to endothelial cells. 2008. Cancer Research. 68 (12): pp.1210.
• This article was highlighted in Nature Reviews Cancer. Wrighton, K. Angiogenesis: Survival of the Infected. Vol.8, 569 (August 2008).
• This article was highlighted on the UCSD-Nature Signaling Gateway web.
44. O’Hara, AJ, Wang, L., Dezube, B., Harrington, WJ, B. Damania and DP Dittmer. Tumor suppressor micro RNAs are underrepresented in primary effusion lymphoma & Kaposi sarcoma. 2009. Blood. 113(23):5938-41
45. O'Hara, AJ, Chugh, P. Wang, L., Netto,E., Luz,E., Harrington, W., Dezube, B., B. Damania, and DP Dittmer. Pre-Micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma. 2009. PloS Pathogens. 5(4):e1000389.
46. Gregory, S. West, JA, Dillon, PJ, Hilscher, C.,Dittmer,DP and B. Damania. Toll like receptor signaling
controls reactivation of KSHV from latency. 2009. PNAS. 106(28):11725-30.
• This article was highlighted in Science Signaling. L. Bryan Ray. For Whom the Toll-Like Receptor Signals. 2, ec242 (July 2009).
47. Wen, KW, Dittmer, DP and B. Damania. Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus. 2009. Journal of Virology. (19):9786-802
48. Wen, KW and B. Damania. Kaposi Sarcoma-associated Herpesvirus (KSHV): Molecular Biology and Oncogenesis. 2009. Cancer Letters. ;289(2):140-50.
49. Gonzalez, CM, Wang, L. and B. Damania. KSHV encodes a viral deubiquitinase. 2009. Journal of Virology. 83(19):10224-33.
50. Gregory, SM and B. Damania. KSHV and the Toll of Innate Immune Activation.2009. Cell Cycle. 15;8(20):3246-7
51. Bhatt, AP, Bhende P, Sin, H., D. Dittmer, B. Damania. Dual Inhibition of PI3K and mTOR Inhibits Autocrine and Paracrine Proliferative Loops in PI3K/Akt/mTOR-addicted Lymphomas. Blood. 2010. 115(22):4455-63.
52. Moyo, TK, Richards, K., and B. Damania. Use of Cidofovir for the Treatment of HIV-negative Human Herpes Virus-8 Associated Primary Effusion Lymphoma. Advances in Clinical Hematology and Oncology. 2010. 8(5):372-4.
53. West, JA and B. Damania. KSHV and Innate Immunity. Future Virology. 2010. 5(2):185-196.
54. Wen, KW and B. Damania. Hsp90 and Hsp40 are required for the anti-apoptotic function of K1. Oncogene. 2010. Apr. 26.
55. Bhende, PM, Lim, M, Parks, SI, Dittmer, DP and B. Damania. The Dual PI3K/mTOR Inhibitor, NVP-BEZ235, is Efficacious against Transformed Follicular Lymphoma. Leukemia. 2010.
56. Ozgur S, Damania B, Griffith J. The Kaposi's sarcoma-associated herpesvirus ORF6 DNA binding protein forms long DNA-free helical protein filaments. J Struct Biol. 2010.
57. West, JA, Gregory SM, Sivaraman V, Su L, and B. Damania. Activation of Plasmacytoid Dendritic Cells by KSHV. 2011. J. Virology.
58. Gregory,SM, Davis,BK., West, JA., Taxman, D., Matsuzawa, S., Reed, J., Ting. JP, and B. Damania. Discovery of a Viral NLR homolog that Inhibits the Inflammasome. Science. 2011. 331(6015):330-4.
This article was highlighted in the following journals:
• Da Silva, K. Editors’ Choice: Evasion through evolution. Nature Medicine 2011 March Vol 17, Issue 3, p. 256.
• Sanchez, C. Research Highlight: Viral immune evasion: NLR identity theft. Nature Reviews Microbiology 2011 March Vol. 9, p. 148-149.
• Dempsey, L. Research Highlight: Viral inflammasome inhibitor. Nature Immunology 2011 February 15, Vol. 12, p. 203
• Mueller, K. Editors’ Choice: Immune Evasion tactic. Science Signaling. 2011 January 25, Vol 4, Issue 157, p.ec27.
• F1000 Biology by Dr. Grant McFadden: Mcfadden, G: Faculty of 1000, 07 Feb 2001. F1000.com/8136972
• F1000 Biology by Dr. Patrick Moore: Dresang L, Moore P: Faculty of 1000, 28 Feb 2011. F1000.com/8136972
59. Gregory, SM., and B. Damania. Virus encoded homologs of cellular NLRs: a new class of viral innate immune response inhibitors. Communicative and Integrative Biology. 2011. Volume 4, Issue 4. Pages 416 – 418
60. Roy D, Sin SH, Damania B, Dittmer DP. Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines. Blood. 2011.
61. Guilluy, C*, Zhang, Z*, Bhende, PM, Sharek, L, Wang, L, Burridge, K, and B. Damania. Latent KSHV Infection Increases the Vascular Permeability of Human Endothelial Cells. Blood. 2011.
62. Dittmer DP, Bhatt AP, B. Damania. Rapalogs in viral cancers. Expert Opin Investig Drugs. 2012. 21(2):135-8.
63. Wang, L, Gregory, S., West, J. Dittmer, DP and B. Damania. Latent KSHV infection of monocytes downregulates expression of adaptive immune response costimulatory receptors and proinflammatory cytokines. J. Virology. 2012.
64. Gregory, SM, West, J, and B. Damania. Cancer vaccination, will you have to pay the toll? Journal of Vaccines & Vaccination. 2012.
65. Dittmer, DP, KL Richards, B. Damania. Treatment of Kaposi sarcoma associated herpesvirus (KSHV) associated cancers. Frontiers in Virology, 2012.
66. Lei, Y, Wen, H, Yu, Y., Taxman, DJ, Zhang, L.,Widman,DG., Swanson,KV,Wen,KW, Damania, B., Moore,CB, Giguère,PM, Siderovski,DP, Hiscott, J., Razani,B.,Semenkovich,CF., Chen, X, and J. P-Y. Ting. The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. Immunity, 2012. 36(6):933-46.
67. Jacobs, SR. and B. Damania. NLRs, Inflammasomes, and Viral Infection. Journal of Leukocyte Biology. 2012. Sep;92(3):469-77.
68. Bhatt, AP, Jacobs, SR, Freerman, A.,Makowski, L., Rathmell, JC., Dittmer, DP, and B. Damania.Dysregulation of Fatty Acid Synthesis and Glycolysis in Non-Hodgkin Lymphoma. 2012. Proceedings of the National Academy of Sciences (PNAS). 109(29):11818-23.
69. Damania B, Blackbourn DJ. Innate barriers to viral infection. Future Microbiol. 2012.7:815-22.
70. Tamburro KM, Yang D, Poisson J, Fedoriw Y, Roy D, Lucas A, Sin SH, Malouf N, Moylan V, Damania B, Moll S, van der Horst C, Dittmer DP. Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A. Virology. 2012.
71. West JA, Gregory SM, B. Damania. Toll-like receptor sensing of human herpesvirus infection. Front Cell Infect Microbiol. 2012. 2:122. doi: 10.3389/fcimb.2012.00122.
72. Jacobs SR, Gregory SM, West JA, Wollish AC, Bennett, CL., Blackbourn DJ, Heise MT, B. Damania. The KSHV vIRFs differ in their inhibition of interferon activation mediated by TLR3. J Virol. 2012 Oct 31.
• This article was highlighted as a Journal of Virology Spotlight feature.
73. Chen W, Sin SH, Wen KW, Damania, B, and DP Dittmer. Hsp90 Inhibitors Are Efficacious against Kaposi Sarcoma by Enhancing the Degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins. PLoS Pathog. 2012 Nov;8(11):e1003048. doi: 10.1371/journal.ppat.1003048.
74. Bhatt AP and B. Damania. AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV. Front Immunol. 2013. 3:401. doi: 10.3389/fimmu.2012.00401.
75. Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR. Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors. J Immunol. 2013. 190(5):2311-9.
76. Roy D, Sin SH, Lucas AS, Venkataramanan R, Wang L, Eason A, Chavakula V, Tamburro KM, Hilton IB, Damania B, Dittmer DP. mTOR inhibitors stall Kaposi sarcoma growth by inhibiting essential autocrine growth factors and tumor angiogenesis. Cancer Research. 2013. 73(7):2235-46.
77. Dillon, PJ, Gregory, SM, Tamburro, K, Sanders, M, Johnson, GL, Raab-Traub, N, Dittmer, DP, and B. Damania. Tousled-like Kinases Modulate Reactivation of Gammaherpesviruses from Latency. Cell Host & Microbe. 2013. 13(2):204-14.
• This article was highlighted by F1000 Biology. http://f1000.com/prime/717982020
78. Yanik, E, Tamburro, K, Eron, JJ, Damania, B., Napravnik, S and DP Dittmer. Kaposi Sarcoma and recent cancer incidence trends in a cohort of HIV-infected individuals in the US. 2013. Infect Agent Cancer. 2013. 24;8(1):18.
79. Meckes, DG, Gunawardena, HP, Dekroon, RM, Heaton, PR, Edwards, RH, Griffith, JD, Damania, B and N. Raab-Traub. Modulation of B-Cell Exosome Proteins by Gammaherpesvirus Infection. Proceedings of the National Academy of Sciences (PNAS). 2013.
80. Chugh, PE, Sin, SH, Ozgur, S, Henry, DH, Menezes, P, Griffith, J, Eron, JJ, Damania, B. and DP Dittmer. Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies. PLoS Pathogens. 2013.
81. Dittmer, DP and B. Damania. Kaposi sarcoma associated herpesvirus pathogenesis (KSHV) – an update. Current Opinion in Virology. 2013.
82. Hilton, I, Davis, I, Damania, B., Lieb, J, and DP Dittmer. Profiling the KSHV epigenome. 2013. Journal of Virology. 87(21):11831-42
83. Giffin, L. and B. Damania. KSHV: Pathways to Tumorigenesis and Persistent Infection. Advances in Virus Research. 2014. Adv Virus Res. 2014;88:111-59.
84. Bentz, GL, Bheda-Magle, A, Wang, L, Shackelford, J, Pagano, JS*, Damania, B*. KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation. Virology. 2014. 448:293-302.
* indicates co-corresponding authors
85. West, JA, Wicks, M, Gregory, SM, Chugh, P, Jacobs, SR, Zhang, Z, Host, KM, Dittmer, DP, and B. Damania. An important role for MAVS in the KSHV lifecycle. J. Virology. 2014.
86. Giffin L, Damania B. KSHV: pathways to tumorigenesis and persistent infection. Adv Virus Res. 2014;88:111-59.
87. Zhang, L, Mo, J, Seanson, KV, Wen, H, Petrucelli, A, Gregory, SM, Zhang, Z, Schneider, M, Jiang, Y, Fitzgerald, K, Ouyang, S, Liu, ZJ, Damania, B., Shu, HB, Duncan, JA, Ting, JP. Immunity. NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING. 2014. 40(3):329-41.
88. Anders, P., Bhende, PM., Foote, M., Dittmer, DP, Park, SI and B. Damania. Dual inhibition of the PI3K/mTOR and MAPK pathways in Non-Hodgkin Lymphoma. Leukemia & Lymphoma. 2014. 1-4.
89. Giffin, L. Yan, F., Major, MB and B. Damania. Modulation of KSHV vIL-6 function by Hypoxia Upregulated Protein 1. J Virol. 2014;88(16):9429-41.
90. Damania, B and D. Dittmer. What lies within: Co-infections and Immunity. Cell Host Microbe. 2014. 16(2):145-7.
91. Chugh, P, B. Damania, and D. Dittmer. Toll-like receptor-3 is dispensable for the innate microRNA response to West Nile Virus (WNV). 2014. PLoS One. 9(8):e104770.
92. Hosseinipour, MC, Sweet, KM, Xiong, J, Namarika,D, Mwafongo, A, Nyirenda, M, Chiwoko,L, Kamwendo, D, Hoffman, I, Lee, J, Phiri, S, Vahrson, W, Damania, B, Dittmer, DP. Viral profiling identifies multiple sub-types of Kaposi sarcoma. mBIO. 5(5):e01633-14.
93. Sun C, Schattgen SA, Pisitkun P, Jorgensen JP, Hilterbrand AT, Wang LJ, West JA, Hansen K, Horan KA, Jakobsen MR, O'Hare P, Adler H, Sun R, Ploegh HL, Damania B, Upton JW, Fitzgerald KA, Paludan SR. Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection. J Immunol. 2015. pii: 1402495.
94. Walker, MP, Stopford, CM, Rabinowitz,AR, Goldfarb,G, Yan, F, Fedoriw, Y, Richards, KL, Damania, B, and Major, MB. FOXP1 Activates Wnt Signaling in Diffuse Large B-cell Lymphoma. Science Signaling. 2015.
95. Frick, A, Fedoriw, Y, Richards, K, Damania, B, Parks, B, Suzuki, O, Benton, C, Chan, E, Thomas R, Wiltshire, T. Immune cell-based screening assay for response to anti-cancer agents: Applications in pharmacogenomics. 2015. Pharmgenomics Pers Med.8:81-98.
96. Zhe, M, Jacobs, SR, West, J., Stopford, CM, Davis, Z, Glaunsinger, B, Dittmer, DP and B. Damania. Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses. Proceedings of the National Academy of Sciences (PNAS). 112(31):E4306-15. doi: 10.1073/pnas.1503831112
97. Damania, B and P. Lieberman. Viruses and cancer. Curr Opin Virol. 2015. S1879-6257(15)00137-6.
98. Jacobs SR, Stopford CM, West JA, Bennett CL, Giffin L, Damania B. KSHV vIRF1 interacts with a member of the Interferon Stimulated Gene 15 pathway. J Virol. 2015.
99. Dittmer DP, Damania B, Sin SH. Animal models of tumorigenic herpesviruses-an update. Curr Opin Virol. 2015.
100. Giffin L, West JA, Damania B. Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration. mBio. 2015. Dec 8;6(6).
101. Ma, Z, B. Damania. NLRP3: Immune Activator or Modulator? Journal of Leukocyte Biology. 2016.
102. Ma, Z., B. Damania. The cGAS-STING Defense Pathway and Its Counteraction by Viruses. Cell Host Microbe. 19, 150-158, 2016.
103. Dissinger, N., B. Damania. Recent advances in understanding Kaposi’s sarcoma-associated herpesvirus. F1000 Reviews. 2016.
104. Host, KM and B. Damania. Discovery of a Novel Bat Gammaherpesvirus. 2016. mSphere.
105. Damania, B. A Virological Perspective on Cancer. PLoS Pathog. 2016 Feb 11;12(2):e1005326.
106. Guo, H, Konig, R, Deng, M, Riess, M, Mo, J., Zhang, L, Petrucelli, A, Yoh, SM, Barefoot, B, Ventevogel, M, Sempowski, GD, Zhang, A, Colberg-Poley, AM, Feng, H, Lemon, SM, Liu, Y., Zhang, Y., Wen, H., Zhang, Z, Damania, B, Tsao, L, Wang, Q, Su, L, Duncan, JA, Chanda, SK, Ting, JP. NLRX1 antagonizes STING to attenuate innate immunity and promote replication of HIV-1 and DNA viruses. Cell Host Microbe. 2016. 19(4):515-28.
107. Johnson, A, Qin, Y., Freerman, A., Huang, MJ., Cozzo, A., Zhao, L., Coleman, R., Sampe, B., Milner, J., Beck, MA., Edin, ML., Zeldin, D., Galanko, JA., Fueger, P., Damania, B., Wu, Y., Mohlke, K., Bivins, B., Stahl, A., L. Makowski. Macrophage Fatty Acid Transporter 1 (FATP1) Drives Alternative Macrophage Polarization and Limits Obesity-Induced Inflammation. Molecular Metabolism, 2016.
108. Zhang, Z., Chen, W., Sander, MK, Brulois, KF, Dittmer, DP, B. Damania. The K1 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) augments viral lytic replication. J. Virology. 2016. 90(17):7657-66. doi: 10.1128/JVI.03102-15.
• This article was selected as a J. Virology Spotlight Feature
109. Bhatt, AP, Wong, JP., Weinberg, MS, Host, KM, Giffin, LC, Buijninkc, J., van Dijkc, E., Izumiya, K, Kung,HJ, Temple, B, and B. Damania. A viral kinase mimics S6 kinase to enhance cell proliferation. PNAS. 2016. Jul 12;113(28):7876-81. doi: 10.1073/pnas.1600587113.
110. Hsia, HC., Stopford C, Zhang, Z, Damania, B., A.S. Baldwin. Protective Role of STAT3 in Myeloid Cells during Herpes Simplex Virus-1 Infection in C57BL/6 Mice. 2016. Journal of Leukocyte Biology. pii: jlb.4A1016-199RR.
111. Eason AB, Sin SH, Lin C, Damania B, Park S, Fedoriw Y, Bacchi CE, Dittmer DP. Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human. Oncotarget. 2016 Aug 23. doi: 10.18632/oncotarget.11531
112. Baric RS, Crosson S, Damania B, Miller SI, Rubin EJ. Next-Generation High-Throughput Functional Annotation of Microbial Genomes. MBio. 2016 Oct 4;7(5). pii: e01245-16. doi: 10.1128/mBio.01245-16.
113. Dittmer, DP and B. Damania. Kaposi sarcoma-associated herpesvirus: immunobiology, oncogenesis, and therapy. Journal of Clinical Investigation. 2016. 126(9):3165-75.
114. Anders, PM, Zhang,Z, Bhende,PM, Giffin,LC and B. Damania. The KSHV K1 Protein Modulates AMPK Function to Enhance Cell Survival. PLoS Pathogens. 2016. 12(11):e1005985. doi:10.1371/journal.ppat.1005985.
115. Host KM, Horner MJ, van der Gronde T, Moses A, Phiri S, Dittmer DP, Damania B, Gopal S. Kaposi's sarcoma in Malawi: a continued problem for HIV-positive and HIV-negative individuals. AIDS. 2017 Jan 14;31(2):318-319
116. Wong JP, Damania B. Modulation of oncogenic signaling networks by Kaposi's sarcoma-associated herpesvirus. Biol Chem. 2017 Jul 26;398(8):911-918.
117. Ma Z, Hopcraft SE, Yang F, Petrucelli A, Guo H, Ting JP, Dittmer DP, Damania B. NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency. PLoS Pathog. 2017 May 1;13(5):e1006350.
118. Hopcraft SE, Damania B. Tumour viruses and innate immunity. Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732).
119. Host KM, Jacobs SR, West JA, Zhang Z, Costantini LM, Stopford CM, Dittmer DP, Damania B. Kaposi's Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes. MBio. 2017 Oct 10;8(5).
120. McNamara, RP, Costantini, LM, Myers, A, Maness, N, Griffith JD, Damania, B., MacLean, AG, and DP Dittmer. Nef secretion into Extracellular Vesicles or exosomes is conserved across human and simian immunodeficiency viruses. mBio, 2018.
121. Anders PM, Montgomery, ND, Montgomery, SA, Bhatt, AP, Dittmer, DP and Damania, B. (2018) A human herpesvirus encoded kinase induces B cell lymphomas in vivo. Journal of Clinical. 2018 Jun 1;128(6):2519-2534.
• This article was highlighted by the JCI Editor. https://www.ncbi.nlm.nih.gov/pubmed/29733293
122. Zhang Y, Dittmer DP, Mieczkowski PA, Host KM, Fusco WG, Duncan JA, Damania B. RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner. 9(4). pii: e00823-18
123. Hopcraft SE, Moody CA, Damania B. Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma. mSphere. 2018 Jul 18;3(4).
124. McNamara RP, Caro-Vegas CP, Costantini LM, Landis JT, Griffith JD, Damania BA, Dittmer DP. Large-scale, cross-flow based isolation of highly pure and endocytosis-competent extracellular vesicles. J Extracell Vesicles. 2018 Nov 30;7(1):1541396
125. Ni G, Ma Z, Damania B. cGAS and STING: At the intersection of DNA and RNA virus-sensing networks. PLoS Pathog. 2018 Aug 16;14(8):e1007148.
126. Ma Z, Ni G, Damania B. Innate Sensing of DNA Virus Genomes. Annu Rev Virol. 2018 Sep 29;5(1):341-362.
127. Dittmer DP, Damania B. Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Associated Disease in the AIDS Patient: An Update. Cancer Treat Res. 2019;177:63-80.
128. Hopcraft SE, Pattenden SG, James LI, Frye S, Dittmer DP, Damania B. Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS Pathog. 2018;14(9):e1007267.
129. Cesarman, E, Damania, B, Krown, SE, Martin, J, Bower, M and D. Whitby. Kaposi Sarcoma. Nature Reviews Disease Primer. 2019. 5(1):9.
130. Caro-Vegas, C, Bailey, AG, Bigi, R, Damania, B, Dittmer DP. Targeting mTOR with MLN0128 overcomes rapamycin and chemoresistant primary effusion lymphoma. mBio. 2019.
131. McNamara RP, Chugh PE, Bailey A, Costantini LM, Ma Z, Bigi R, Cheves A, Eason AB, Landis JT, Host KM, Xiong J, Griffith JD, Damania B, Dittmer DP. PLoS Pathog. 2019 Feb 4;15(2):e1007536.
132. Rivera-Soto, R and B. Damania. Modulation of angiogenic processes by the human gammaherpesviruses, Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus. 2019. Frontiers in Microbiology.
133. Wong, JP, Stuhlmiller, TJ, Giffin, LC, Lin, C, Bigi, R, Zhao, J, Zhang W, Bravo Cruz, AG, Park, SI, Earp, HS, Dittmer, DP, Frye, SV, Wang, X, Johnson, GL, Damania, B. Kinome profiling of Non-Hodgkin Lymphoma identifies Tyro3 as a therapeutic target in PEL. 2019. PNAS.
134. Park SI, Lin CP, Ren N, Angus SP, Dittmer DP, Foote M, Parton T, Bhatt AP, Fedoriw YD, Roth DP, Cann ML, Johnson GL, Damania B. Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma.Target Oncol. 2019.
135. Caro-Vegas C, Sellers S, Host KM, Seltzer J, Landis J, Fischer WA 2nd, Damania B, Dittmer DP. Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels. Virology. 2019.
136. Atkins SL, Motaib S, Wiser LC, Hopcraft SE, Hardy PB, Shackelford J, Foote P, Wade AH, Damania B, Pagano JS, Pearce KH, Whitehurst CB. Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1. Antiviral Res. 2019.
137. Lange P, Damania B. Kaposi Sarcoma-Associated Herpesvirus (KSHV). Trends Microbiol. 2019.
138. Montgomery ND, Randall C, Painschab M, Seguin R, Kaimila B, Kasonkanji E, Zuze T, Krysiak R, Sanders MK, Elliott A, Miller MB, Kampani C, Chimzimu F, Mulenga M, Damania B, Tomoka T, Fedoriw Y, Dittmer DP, Gopal S. High pretreatment plasma Epstein-Barr virus (EBV) DNA level is a poor prognostic marker in HIV-associated, EBV-negative diffuse large B-cell lymphoma in Malawi. Cancer Med. 2020.
139. Pluta L, Yousefi B, Damania B, Khan AA. Endosomal TLR-8 Senses microRNA-1294 Resulting in the Production of NFḱB Dependent Cytokines. Front Immunol. 2019
140. Rivera-Soto R, Dissinger NJ, Damania B. Kaposi's Sarcoma-associated Herpesvirus Viral Interleukin 6 Signaling Upregulates Integrin Beta 3 Levels and is Dependent on STAT3. J Virol. 2019.
141. Pluta L, Yousefi B, Damania B, Khan AA. Endosomal TLR-8 Senses microRNA-1294 Resulting in the Production of NFḱB Dependent Cytokines. Front Immunol. 2019 Dec 6;10:2860.
142. Broussard G, Damania B. KSHV: Immune Modulation and Immunotherapy. Front Immunol. 2020 Feb 7;10:3084.
143. Zhang H, Ni G, Damania B. ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway. Cell Rep. 2020 Apr 28;31(4):107564.
144. Wolf ER, Mabry AR, Damania B, Mayo LD. Mdm2-mediated neddylation of pVHL blocks the induction of antiangiogenic factors. Oncogene. 2020 Jul;39(29):5228-5239.
145. Ni G, Ma Z, Wong JP, Zhang Z, Cousins E, Major MB, Damania B. PPP6C Negatively Regulates STING-Dependent Innate Immune Responses. mBio. 2020 Aug 4;11(4):e01728-20.
146. Lange PT, Damania B. Modeling oncogenic herpesvirus infections in humanized mice. Curr Opin Virol. 2020 Oct;44:90-96.
147. Zhang Y, Ma Z, Wang Y, Boyer J, Ni G, Cheng L, Su S, Zhang Z, Zhu Z, Qian J, Su L, Zhang Q, Damania B, Liu P. Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity. iScience. 2020 Aug 14;23(9):101463
148. Broussard G, Damania B. Regulation of KSHV Latency and Lytic Reactivation. Viruses. 2020 Sep 17;12(9):1034.
149. Wang Y, Ma Z, Damania B, Liu P. STAR Protoc. Protocol for Monitoring DNA-Triggered cGAS/STING Signaling in Mammalian Cells and Mice. 2020 Nov 14;1(3):100171.
150. Dittmer D, Damania B. Editorial overview: Viral immunology. Curr Opin Virol. 2020 Oct;44:v-vi.
151. Barzin A, Schmitz JL, Rosin S, Sirpal R, Almond M, Robinette C, Wells S, Hudgens M, Olshan A, Deen S, Krejci P, Quackenbush E, Chronowski K, Cornaby C, Goins J, Butler L, Aucoin J, Boyer K, Faulk J, Alston-Johnson D, Page C, Zhou Y, Fiscus L, Damania B, Dittmer DP, Peden DB. SARS-CoV-2 Seroprevalence among a Southern U.S. Population Indicates Limited Asymptomatic Spread under Physical Distancing Measures. mBio. 2020 Sep 29;11(5):e02426-20.
152. McNamara RP, Caro-Vegas C, Landis JT, Moorad R, Pluta LJ, Eason AB, Thompson C, Bailey A, Villamor FCS, Lange PT, Wong JP, Seltzer T, Seltzer J, Zhou Y, Vahrson W, Juarez A, Meyo JO, Calabre T, Broussard G, Rivera-Soto R, Chappell DL, Baric RS, Damania B, Miller MB, Dittmer DP. High-Density Amplicon Sequencing Identifies Community Spread and Ongoing Evolution of SARS-CoV-2 in the Southern United States. Cell Rep. 2020 Nov 3;33(5):108352.
153. Wang Y, Ma Z, Damania B, Liu P. Protocol for Monitoring DNA-Triggered cGAS/STING Signaling in Mammalian Cells and Mice. STAR Protoc. 2020 Nov 14;1(3):100171. doi: 10.1016/j.xpro.2020.100171.
154. Alzhanova D, Corcoran K, Bailey AG, Long K, Taft-Benz S, Graham RL, Broussard GS, Heise M, Neumann G, Halfmann P, Kawaoka Y, Baric RS, Damania B, Dittmer DP. Novel modulators of p53-signaling encoded by unknown genes of emerging viruses. PLoS Pathog. 2021 Jan 7;17(1):e1009033.
155. Chappell DL, White MC, Damania B. Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis. Adv Virus Res. 2021;109:201-254.
156. Wong JP, Damania B. SARS-CoV-2 dependence on host pathways. Science. 2021 Feb 26;371(6532):884-885.
157. Rivera-Soto R, Yu Y, Dittmer DP, Damania B. Combined Inhibition of Akt and mTOR Is Effective Against Non-Hodgkin Lymphomas. Front Oncol. 2021 Jun 18;11:670275
158. Lange PT, White MC, Damania B. Activation and Evasion of Innate Immunity by Gammaherpesviruses. J Mol Biol. 2021 Aug 23:167214.
159. Wen KW, Wang L, Menke JR, Damania B. Cancers associated with human gammaherpesviruses. FEBS J. 2021
160. Sandhu PK, Damania B. The regulation of KSHV lytic reactivation by viral and cellular factors. Curr Opin Virol. 2021 Dec 3;52:39-47.
161. Carbone A, Borok M, Damania B, Gloghini A, Polizzotto MN, Jayanthan RK, Fajgenbaum DC, Bower M. Castleman disease. Nat Rev Dis Primers. 2021. 7(1):84.
162. McNamara RP, Eason AB, Zhou Y, Bigi R, Griffith JD, Costantini LM, Rudek MA, Anders NM, Damania BA, Dittmer DP. Exosome-Encased Nucleic Acid Scaffold Chemotherapeutic Agents for Superior Anti-Tumor and Anti-Angiogenesis Activity. ACS Bio Med Chem Au. 2022. 2(2):140-149.
163. Casper C, Corey L, Cohen JI, Damania B, Gershon AA, Kaslow DC, Krug LT, Martin J, Mbulaiteye SM, Mocarski ES, Moore PS, Ogembo JG, Phipps W, Whitby D, Wood C. KSHV (HHV8) vaccine: promises and potential pitfalls for a new anti-cancer vaccine. NPJ Vaccines. 2022 Sep 20;7(1):108.
164. Huang N, Groover D, Damania B, Moody C. Apoptotic caspases suppress an MDA5-driven IFN response during productive replication of human papillomavirus type 31. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2200206119.
165. White MC, Wu X, Damania B, Oncogenic viruses, cancer biology, and innate immunity. Curr Opin Immunol. 2022 Oct 11;78:102253.
166. Zhang H, Wong JP, Ni G, Cano P, Dittmer DP, Damania B. Mitochondrial protein, TBRG4, modulates KSHV and EBV reactivation from latency. PLoS Pathog. 2022 Nov 23;18(11):e1010990.
167. Damania B, Kenney SC, Raab-Traub N. Epstein-Barr virus: Biology and clinical disease. Cell. 2022 Sep 29;185(20):3652-3670.
168. Lange, PT and B. Damania. EBV-Positive Lymphomas Exploit Ectonucleotidase Activity to Limit Immune Responses and Prevent Cell Death. mBio. 2023 Apr 25;14(2):e0345922.
169. Broussard, G, Ni, G, Zhang, Z, Li, Q, Cano, P, Dittmer, DP and Damania B. Barrier-to-autointegration Factor 1 Promotes Gammaherpesvirus Reactivation from Latency. Nature Communications. 2023. Feb 6;14(1):434.
170. Chappell DL, Sandhu PK, Wong JP, Bhatt AP, Liu X, Buhrlage SJ, Temple BRS, Major MB, Damania B. KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle. J Virol. 2023 Mar 30;97(3):e0176322.
171. Landis JT, Moorad R, Pluta LJ, Caro-Vegas C, McNamara RP, Eason AB, Bailey A, Villamor FCS, Juarez A, Wong JP, Yang B, Broussard GS, Damania B, Dittmer DP. Intra-Host Evolution Provides for the Continuous Emergence of SARS-CoV-2 Variants. mBio. 2023 Apr 25;14(2):e0344822.
172. Stewart JA, Damania B. Human DNA tumor viruses evade uracil-mediated antiviral immunity. PLoS Pathog. 2023 Mar 30;19(3):e1011252.
173. Zhu Z, Johnson RL, Zhigang Z, Herring LE, Jiang G, Damania B, James LI, Liu P. Development of VHL-recruiting STING PROTACs that suppress innate immunity. 2023. Cell Mol Life Sci. 14;80(6):149.
174. Damania B, Dittmer DP. Today's Kaposi sarcoma is not the same as it was 40 years ago, or is it? J Med Virol. 2023 May;95(5):e28773.
175. Zhang H, Sandhu PK, Damania B. The Role of RNA Sensors in Regulating Innate Immunity to Gammaherpesviral Infections. Cells. 2023 Jun 17;12(12):1650.
176. Moorad R, Kasonkanji E, Gumulira J, Gondwe Y, Dewey M, Pan Y, Peng A, Pluta LJ, Kudowa E, Nyasosela R, Tomoka T, Tweya H, Heller T, Gugsa S, Phiri S, Moore DT, Damania B, Painschab M, Hosseinipour MC, Dittmer DP. A prospective cohort study identifies two types of HIV+ Kaposi Sarcoma lesions: proliferative and inflammatory. Int J Cancer. 2023.
177. Calhoun JC, Damania B, Griffith JD, Costantini LM. Electron microscopy mapping of the DNA-binding sites of monomeric, dimeric, and multimeric KSHV RTA protein. J Virol. 2023 Sep 26:e0063723.
178. Wu XJ, Zhang Z, Wong JP, Rivera-Soto R, White MC, Rai AA, Damania B. Kaposi's sarcoma-associated herpesvirus viral protein kinase augments cell survival. Cell Death Dis. 2023.
179. Castillo Cabrera J, Dang H, Graves A, Zhang Z, Torres-Castillo J, Li K, King Z, Liu P, Aubé J, Bear JE, Damania B, Hagan RS, Baldwin AS. AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms. Cell Chem Biol. 2023 Dec 21;30(12):1601-1616.
180. Rasmussen AL,Damania B….Yurochko A. Virology-the path forward. J Virol. 2024 Mar 19;98(3):e0007424. doi: 10.1128/jvi.00074-24.
181. White MC, Wong JP, Damania B. Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden. Cancer Res Commun. 2024 Apr 9;4(4):1024-1040.
182. Sin SH, Eason AB, Kim Y, Schneider JW, Damania B, Dittmer DP. The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice. Cell Host Microbe. 2024 Apr 15:S1931-3128(24)00112-4.